Ya, here's some pretty strong trends:
1. (As mentioned) the Texans have never won in Indy.
2. Andrew Luck is 8-0 ATS (against the spread) coming off a loss.
3. Andrew Luck has never lost two games in a row.
4. Andrew Luck is 10-4 ATS at home.
5. Colts are 19-4 against the Texans straight up.
Partial source